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Evaluation of Anti‐diabetics and Cardiovascular Effects of a Nigerian poly herbal Extract ( Picralima nitida seed, Acacia nilotica pod and Aristolochia ringens root) on Postprandial and Alloxan Induced Diabetic Albino Rats
Author(s) -
Ani Anthony Amaechi,
Ogbonnia Steve O.,
Okosun Anthonia
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.759.7
Subject(s) - medicine , glibenclamide , gum acacia , postprandial , acacia , traditional medicine , cholesterol , high density lipoprotein , body weight , diabetes mellitus , low density lipoprotein , zoology , endocrinology , chemistry , biology , botany , food science
Twenty Wister strain albino rats were randomly assigned to four groups; A,B, C, and D with each consisting of five animals received extract as follows: 500mg/kg body weight‐bwt; 250mg/kg bwt; 100mg/kg bwt; 0.5mL(2%) acacia solution serve as control. After 30 minutes the animals were administered orally with 40 % (w/v) glucose at a dose 1mL/100 g bwt. Blood glucose level was monitored at 30, 60 and 120 minutes intervals and reports as the average glucose level of each group. Another set of twenty rats were randomly distributed into four groups of five animals each, while the additional fifth group consisting of five normal rats, positive control. Group I: Control rats received 0.5% Acacia suspension;group II: Diabetic rats treated with glibenclamide 600μg/kg bwt; group III: Diabetic rats treated with 250mg extract/kg; group IV: Diabetic rats treated with 500mg extract/kg ; group V: untreated diabetic rats. There was significant reduction (P<0.05) in the plasma glucose level and low density lipoprotein (LDL)‐cholesterol levels, and significant increase in high density lipoprotein (HDL)‐cholesterol levels in the treated diabetic rats compared to the negative control. This results showed that the poly herbal formulation had both good hypoglycemic activities and beneficial effects on cardiovascular risk factors.