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Improvement in blood lipid levels by Eryngium carlinae in diabetic rats
Author(s) -
Noriega-Cisneros Ruth,
Ortiz-Ávila Omar,
Esquivel-Gutiérrez Edgar,
Clemente-Guerrero Mónica,
Manzo-Avalos Salvador,
Salgado-Garciglia Rafael,
Cortés-Rojo Christian,
Saavedra-Molina Alfredo
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.759.5
Subject(s) - creatinine , diabetes mellitus , uric acid , medicine , hyperlipidemia , streptozotocin , endocrinology , cholesterol , lipid profile , triglyceride
Diabetes mellitus is a significant risk factor for the development of cardiovascular complications. This study was undertaken to investigate the effect of chronic administration of ethanolic extract of Eryngium carlinae on glucose, creatinine, uric acid, total cholesterol, and triglycerides levels in serum of streptozotocin (STZ)‐ induced diabetic rats. Triglycerides, total cholesterol, and uric acid levels increased in serum from diabetic rats. The treatment with E. carlinae prevented these changes. The administration of E. carlinae extract reduced the levels of creatinine, uric acid, total cholesterol, and triglycerides. Thus, administration of E. carlinae is able to reduce hyperlipidemia related to the cardiovascular risk in diabetes mellitus. Histopathological studies showed significant changes like necrosis and degeneration in pancreas of diabetic rats, these histopathological abnormalities were not normalized after treatment with the extract.