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Development of an integrated bioenergetics index [IBI] function for biophotonic therapy
Author(s) -
Einstein George Przybyl,
Tulp Orien L,
Karam David
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.731.6
Subject(s) - bioenergetics , immune system , metabolism , bacteria , energy metabolism , biology , function (biology) , microbiology and biotechnology , senescence , host (biology) , chemistry , biophysics , biochemistry , immunology , ecology , genetics , endocrinology , mitochondrion
Bioenergetics forms the basis for ultraviolet phototherapy [UVPT] and processes of cellular metabolism and energy production in health and disease. To quantify the contribution of UVPT on bioenergetics a mathematical formula has been derived and applied to quantify immune‐linked mechanisms that modulate metabolism in normal and disordred states. Energy transfer processes are quantifiable events and are essential for processes that contribute to life, the pathophysiology of disease, and senescence. The effectiveness of UVPT can be explained in part by examining the effect of quanta of UV light on the chemical structure of bacteria and cellular processes. The IBI may be expressed as follows: IBI= C1∙C2∙F1( B/A; N/W;S/E;SM/M) ‐ F2[(VIR_L;Bact_L;TOX_L;FREE_RAD)/(NMicEl_∙NDE TOX NUT )], where determinants of genetic, physiologic, biochemical, nutritional, and other factors are assessed. Bacterial cells are smaller and more susceptible to UV energy than eukaryotic cells due to a 5‐fold greater content of photosensitive amino acids[PSAA], enabling bacteria to absorb greater quanta of UVPT energy than similarly exposed eurkaryotic host cells, effectively “marking” them for demise. In contrast, lower cell content of PSAA in eukaryotic host cells result in less damage during UVPT. These results are consistent with UVPT enhanced humeral and cellular responses to immunogenic stimuli. Institutional Support.