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Aortic depressor nerve differences between Wistar and Wistar‐Kyoto rats
Author(s) -
Aguiar Mendes Vânia Alice,
Amorim Milena Menezes,
Silva Letícia Oliveira Neri,
Salgado Helio Cesar,
Fazan Valéria Paula Sassoli
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.725.7
Subject(s) - anatomy , chemistry , morphology (biology) , body weight , biology , endocrinology , genetics
Previous reports from our laboratory [1, 2, 3] showed differences on the morphology of the aortic depressor nerve (ADN) between normotensive Wistar‐Kyoto (WKY) and spontaneously hypertensive rats (SHR). The aim of the present study was to investigate if there are morphological and morphometric differences on the AND of two different normotensive rats strains. Twelve Wistar rats (WR) and 13 WKY had their left ADN fixed in 2,5% glutaraldehyde. Semithin cross sections of proximal and distal segments of the ADN were analyzed by light microscopy and a morphometric study of the nerve fascicles and myelinated fibers was performed. Comparison between proximal and distal segments of the two strains revealed a longitudinal symmetry. Comparison between strains revealed that, despite the fact that WR are heavier (body weight = 339 ± 17g for WR and 277 ± 54 for WKY) than WKY, ADN fascicles and myelinated fibers are larger in WKY. Myelinated fiber distributions were unimodal in both segments for both strains, with peak in 2,5 μm but, there is a higher percentage of large fibers (> 4 μm) in WKY nerves. Average values of myelinated fibers morphometric parameters are higher in WKY due to a larger number of fibers bigger than 4 μm. Grant Funding Source : FAPESP, CNPq, CAPES and FAEPA