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Duplex Ultrasound Measuring Hemodynamic Variations of the Superior Mesenteric Artery in Pre‐ and Postprandial Subjects: Understanding Mesenteric Ischemia
Author(s) -
Elnekaveh Brandon Mordeccai,
Adar Tony,
Baral Sumit,
Pagano Anthony,
Belyayeva Irina,
Marquez Samuel
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.722.6
Subject(s) - postprandial , medicine , superior mesenteric artery , cardiology , hemodynamics , sma* , blood flow , ischemia , mathematics , combinatorics , insulin
Mesenteric ischemia (MI) is characterized by disabling postprandial abdominal angina stemming from hypoperfusion of the midgut due to inadequate vascular compensatory mechanisms in the superior mesenteric artery (SMA). Duplex ultrasound was used to measure the vascular diameter, peak systolic velocity (PSV), and end diastolic velocity (EDV) of the SMA in 6 healthy subjects after an overnight fast and 30 minutes after eating. Results show a preprandial PSV range of 100.3 – 123.2 cm/s and DV of 18.0 – 26.7 cm/s, and a postprandial PSV of 194.9 – 246.5 cm/s and EDV 41.1 – 73.7 cm/s. All subjects experienced significant increases in SMA postprandial blood velocities (p<.05) with only a slight increase in its diameter (p>.05). In the fasting state, early diastolic flow reversal was observed, yet it was absent postprandially. Normal SMA flow is characterized by a high‐resistance outflow bed in the fasting state. These data suggest that postprandial abdominal pain in MI may indeed be related to increased mesenteric blood flow met by an inadequate vascular response resulting in tissue ischemia. Grant Funding Source : Alumni Association