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Physiological Pathways tool allows intuitive linking of genotype and phenotype data to biological processes in a graphical format
Author(s) -
Munzenmaier Diane H.,
Liu Weisong,
Jacob Howard J.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.717.2
Subject(s) - context (archaeology) , computational biology , biology , phenotype , biological pathway , bioinformatics , neuroscience , gene , genetics , gene expression , paleontology
The Rat Genome Database (RGD) has recently developed a new feature called Physiological Pathways that graphically depicts various physiological systems, allowing intuitive and informative linking of physiological processes to related phenotype and genotype information. These pathways are designed to complement and integrate with the existing molecular pathway features in RGD, allowing coverage of processes that occur within and between cells, tissues, and organs. The user can begin with a pathway of interest and drill down to find information on involved genes, as well applicable strain reports, phenotype data, etc. Alternatively, one can begin at the level of a gene of interest and zoom out to determine physiological and pathological context for the associated gene product. Physiological Pathways are continually growing and being updated with new pathways in a variety of organ systems. Pathways are currently being added in a manner that attempts to cover a wide range of processes including those in the areas of cardiovascular (vasoconstriction), renal (vasopressin‐mediated water reabsorption), and neuroendocrine (insulin release regulation and action). This new feature promises to be an effective and user‐friendly tool with which to access and retrieve physiological and genomic data for researchers who use the rat as a model to study biological processes and their modulation.