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Relationship between total expired air, peak airflow, and cough number in reflex cough
Author(s) -
Hegland Karen Wheeler,
Davenport Paul W
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.704.19
Subject(s) - cough reflex , medicine , anesthesia , chronic cough , inhalation , reflex , expiration , airway , airflow , respiratory system , asthma , mechanical engineering , engineering
Reflex cough typically includes multiple cough reaccelerations. The relationship between total expired air volume, peak flow rate and cough volume acceleration has been investigated for multiple reaccelerations during voluntary cough; these data are not available for reflex cough. The goal of this study was to investigate the relationship between reflex cough reaccelerations and cough airflow parameters. Twenty healthy adults volunteered to participate. Participants were seated and outfitted with a facemask and pneumotacograph. Capsaicin (200μM) was delivered via dosimeter attached to the facemask. Cough airflow was recorded across 3 reflex cough trials. Cough epochs (all cough reaccelerations associated with one inhalation) ranged from two (C2) to six (C6) cough reaccelerations. Total expired volume ranged from 1.05 to 2.20 liters of air. The percent of total expired air for a cough was linearly related to the total number of coughs in a cough epoch, peak expiratory flow rate, and cough volume acceleration. Results indicate that greater number of cough reaccelerations in an epoch redistribute the rate and amount of air expired for each cough. Because the rate of airflow during a cough directly contributes to the shearing forces that clear material from the airway, increasing number of cough reaccelerations in an epoch may decrease overall cough effectiveness.