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Impact of sleep disordered breathing and arousal state on the hypoxic ventilatory response and ventilatory long‐term facilitation
Author(s) -
Syed Ziauddin,
Lin Ho-Sheng,
Mateika Jason H.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.704.14
Subject(s) - wakefulness , medicine , arousal , hypoxic ventilatory response , obstructive sleep apnea , anesthesia , intermittent hypoxia , hypoxia (environmental) , sleep (system call) , facilitation , control of respiration , sleep and breathing , apnea , cardiology , respiratory system , psychology , oxygen , chemistry , electroencephalography , neuroscience , computer science , operating system , organic chemistry , psychiatry
Purpose To examine the impact of sleep disordered breathing and arousal state on the magnitude of the hypoxic ventilatory response (HVR) and ventilatory long‐term facilitation (vLTF) during and after exposure to intermittent hypoxia (IH), respectively. Methods Ten healthy males and 8 males with obstructive sleep apnea (OSA) were exposed to IH on two occasions; once during wakefulness and the other during sleep. The IH protocol consisted of 12‐2 min episodes of hypoxia (P ET O 2 – 50 mmHg) in the presence of P ET CO 2 levels sustained 3 mmHg above baseline. Each episode was followed by a 2 min normoxic recovery period with the exception of the last recovery period which was 30 min in duration.Control OSA Wake Sleep Wake SleepHVR 0.61±0.07* 0.46±0.06 0.64±0.10* 0.51±0.14 V E 1.19±0.03*§ 1.09±0.03§ 1.37±0.11*§† 1.13±0.05§† V T 1.13±0.02*§ 1.08±0.03§ 1.27±0.07*§ 1.09±0.05§ B f 1.06±0.03§ 1.00±0.01 1.08±0.04§ 1.03±0.03V E , V T , B f ‐standardized to baseline. Significantly different from sleep (*) and baseline (§) p < 0.05. Trend toward a difference from control (†) p < 0.07.Results & Conclusions vLTF was evident during wake and sleep; however, the magnitude of vLTF as well as HVR was greater during wakefulness. The magnitude of vLTF tended to be greater in the OSA group compared to control. V T was the primary component responsible for vLTF during sleep while B f also contributed to vLTF during wakefulness. Funding: VA Merit & NIH