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Effect of acetylcholinesterase blockade with pyridostigmine on baroreflex and cardiovascular autonomic control in heart failure rats, six to seven weeks after coronary artery ligation
Author(s) -
Sabino Joao Paulo Jacob,
Silva Carlos Alberto Aguiar,
Junior Rubens Fazan,
Salgado Helio Cesar
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.703.4
Subject(s) - baroreflex , heart rate , pyridostigmine , medicine , atropine , blood pressure , propranolol , heart failure , heart rate variability , autonomic nervous system , cardiology , parasympathetic nervous system , anesthesia , myasthenia gravis
We evaluated in conscious heart failure (HF) rats the effect of acetylcholinesterase blockade with pyridostigmine (PYR) on systolic arterial pressure (SAP) variability (spectral analysis), baroreflex effectiveness index (Δ heart rate/Δ mean arterial pressure; bpm/mmHg), parasympathetic control of the heart (Δ heart rate after atropine; bpm) and intrinsic heart rate (heart rate after atropine plus propranolol; bpm). HF rats showed smaller power in the low frequency (LF, mmHg2) band of SAP spectrum [1.2±0.2 (n=10) vs. 3.3±0.4 in control rats (n=9)] while PYR prevented this reduction [2.9±0.8 (n=9)]. The baroreflex effectiveness index was attenuated in HF rats [−1.3±0.1 (n=9) vs. − 2.4±0.4 in control rats (n=11)] while PYR prevented this attenuation [−2.4±0.3 (n=9)]. The parasympathetic tonus was attenuated in HF rats [39±12 (n=7) vs. 90±15 in control rats (n=7)] while PYR prevented this attenuation [77±7, (n=6)]. Intrinsic heart rate was reduced in HF rats [363±7 (n=13) vs. 401±8 in control rats (n=14)], while PYR impaired this reduction [408±5 (n=12)]. In conclusion, blockade of acetylcholinesterase with PYR in HF rats was efficient to protect the autonomic control of SAP variability, the parasympathetic tone to the heart, the baroreflex sensitivity and the intrinsic heart rate. Therefore, an increase in parasympathetic function plays a benefic role in the development of HF.