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Effect of Some Antioxidant Vitamins on Some Enzymes of Ocular Tissues Exposed to Potassium Bromate
Author(s) -
Osagie Victor Ehigie,
Okolie Paulinus Ngozi
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.692.14
Subject(s) - catalase , malondialdehyde , superoxide dismutase , potassium bromate , chemistry , antioxidant , saline , zoology , cornea , body weight , endocrinology , medicine , biochemistry , ophthalmology , biology , catalysis
The effects of potassium bromate on ocular tissues (lens, retina and cornea) and subsequent treatment with antioxidant vitamins (A, C and E) on New Zealand white rabbits were studied for a period of eight weeks. Three groups of eight rabbits each were used. One test group (B) was administered 60mg KBrO 3 /kg body weight/day. The other test group, BV, was in addition to KBrO 3 given 200,000IU vit. A/kg body weight/day, 1000IU vit. E/kg body weight/day and vit. C 40mg/kg body weight/day. The control group (N) received only normal saline. The study considered the levels of malondialdehyde (MDA), catalase and superoxide dismutase (SOD) in the ocular tissues. The results show that the lenticular SOD activity of the B group was significantly higher (p<0.05) than the control while the BV recorded an insignificant (p>0.05) increase over the control. The B and BV groups recorded significant increases in corneal SOD activity over the control. The BV group showed significant increase (p<0.05) in catalase activity when compared with N and B groups of all the tissues. The retinal MDA concentration recorded a significant increase (p<0.05) when the B group is compared with the control but no significant difference (p>0.05) between the BV and N. The corneal MDA level did not record any significant change (p>0.05) but the lenticular MDA level recorded a significant increase (p<0.05). This preliminary study indicates that potassium bromate adversely affects ocular tissues, and that antioxidant vitamins may play a role in mitigating these effects.