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Renal responses to severe haemorrhage in conscious lambs
Author(s) -
Smith Francine Gabriel,
Samhan Mohamed,
Qi Wei
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.690.16
Subject(s) - renal function , renal blood flow , medicine , urinary system , urology , endocrinology
The role of the kidney in the physiological responses to severe degrees of haemorrhage beyond which compensatory mechanisms fail (>25% of vascular volume) has not been investigated in the newborn period. In this study, parameters of glomerular and tubular function were measured for 30 min before (Control, C) and 120 min after haemorrhage of 30% of vascular volume, in conscious, chronically instrumented lambs aged ~one (N=10) and ~six weeks (N=9). Renal plasma flow decreased 30 min after haemorrhage from 1.4±0.5 SD (C) to 0.7±0.2 mL.min −1 .g −1 at one week and from 1.6±0.4 (C) to 0.9±0.4 mL.min −1 .g −1 at six weeks and remained decreased at 120 min. Similarly, glomerular filtration rate decreased from 0.26±0.08 (C) to 0.18±0.14 mL.min −1 .g −1 at one week and from 0.31±0.08 (C) to 0.17±0.08 mL.min −1 .g −1 at six weeks, and remained below C at 120 min. Urinary flow rate also decreased from 3.8±1.6 (C) to 1.8±0.7 uL.min −1 .g −1 by 30 min after haemorrhage at one week and from 3.9±1.5 (C) to 2.2±0.8 uL.min −1 .g −1 at six weeks, and remained below C at 120 min. Clearances of Na + and K + also decreased after haemorrhage in both age groups. These data provide evidence that soon after birth, glomerular and tubular responses to severe blood loss are elicited, though they do not appear to be developmentally regulated. [Supported by the Canadian Institutes of Health Research.]