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Anti‐diabetic effect and acute toxicity of the water extract of Cyperus rotundus L. in rats
Author(s) -
Krisanapun Chutwadee,
Wongkrajang Yuvadee,
Temsiririrkkul Rungravi,
Kongsaktrakoon Boontium,
Peungvicha Penchom
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.686.8
Subject(s) - cyperus rotundus , diabetes mellitus , flatulence , medicine , rhizome , acute toxicity , toxicity , traditional medicine , insulin , glucose tolerance test , pharmacology , endocrinology , insulin resistance
Herbal medicine is a complementary and alternative medicine which spread in many conditions/diseases, including diabetes mellitus. Cyperus rotundus L. in Cyperaceae family is a traditional herb found in Thailand. Although, some activities such as diuresis, flatulence and skin diseases had the scientific support, anti‐diabetic effect is not yet exhibited. So, the aim of this study was to examine the anti‐diabetic, toxicity and 2 mechanisms of action of C. rotundus 's rhizome. The extraction of the rhizome with water got the yield around 10% w/w of dry plant. The results of the oral glucose tolerance test revealed that the extract 0.5 g/kg could significantly reduce the plasma glucose levels of either type 1 or type 2 diabetic rats comparing with control diabetic group. The toxicity test could summarize the single oral LD 50 was more than 5 g/kg. The mechanism testing demonstrated that the extract at a dose of 5 mg/ml could inhibit the intestinal glucose absorption significantly in everted sac model and the extract since 1 mg/ml could enhance the glucose utilization of muscle like insulin did. We can conclude that the C. rotundus extract has a hypoglycemic or anti‐diabetic effect by inhibiting intestinal glucose absorption and promoting glucose consumption. Thus, it is very interesting for developing the extract to, at least, adjuvant for diabetes patients in the future. This work was support by Mahidol University, Thailand.