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Effects of acute moderate‐ and high‐intensity exercise on glucose disposal and beta‐cell function
Author(s) -
Rynders Corey A,
Chan Alice,
Weltman Judy Y,
Barrett Eugene J,
Weltman Arthur
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.686.24
Subject(s) - postprandial , medicine , area under the curve , insulin , endocrinology , glycemic , insulin resistance , ingestion
The effects of isoenergetic high (HIE) and moderate intensity (MIE) cycle ergometer exercise on glucose disposal and beta‐cell function were examined in nine sedentary pre‐diabetic adults. Subjects completed 3 conditions with order randomized: HIE (84% VO2peak), MIE (51% VO2peak), and seated rest (C). One‐hour post‐exercise (or C), subjects received a 3‐hr OGTT. Plasma glucose, insulin, and C‐peptide concentrations were measured before and at 5–10min intervals after glucose ingestion. The incremental area under the glucose curve was calculated for the 0–60min (AUC‐1), 60–120min (AUC‐2), and 120–180min (AUC‐3) time intervals. Deconvolution analysis of C‐peptide quantified insulin secretion rate. Beta‐cell function was assessed using the insulin secretion/insulin resistance index. Compared to C, HIE decreased the mean glucose AUC‐2 by 36% (p=0.03) and AUC‐3 by 42% (p=0.003) whereas MIE tended to reduce AUC‐3 by 21% (p=0.06). Glucose AUC‐2 was 27% lower after HIE compared to MIE (p=0.008). A trend for improved beta‐cell function was observed after HIE (C=0.34±0.05; MIE=0.36±0.16; HIE=0.42±0.17; p=0.17, C vs. HIE). These results suggest that exercise has an intensity dependent effect to improve postprandial glycemic excursion which may in part be related to acute enhancements in beta‐cell function. This research was supported by grant funding from Virginia's Commonwealth Health Research Board.