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Impaired dynamic cerebral autoregulation in type 2 diabetes patients is associated with elevated oxidative stress
Author(s) -
Deo Shekhar H,
Vianna Lauro C,
Kim Areum,
Zimmerman Matthew C,
Fadel Paul J
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.685.8
Subject(s) - oxidative stress , medicine , type 2 diabetes , endocrinology , diabetes mellitus , reactive oxygen species , chemistry , biochemistry
Previous studies have indicated that an elevation in oxidative stress within the rat brain impairs cerebral autoregulation (CA). Patients with type 2 diabetes (T2D) have been shown to exhibit elevated systemic oxidative stress. However, whether this increase in oxidative stress is associated with impairments in CA at rest or during exercise remains unclear. In 12 men, 6 T2D patients and 6 age‐matched controls, middle cerebral artery blood velocity and blood pressure (BP) were measured at rest and during static handgrip performed at 40% MVC. Dynamic CA was assessed using the rate of regulation (RoR) and total reactive oxygen species (ROS) was measured using electron paramagnetic resonance (EPR) spectroscopy. Compared to controls, patients with T2D had a lower RoR at rest that was further reduced during handgrip suggesting an impaired dynamic CA. Furthermore, T2D demonstrated greater baseline total ROS compared to controls (1.1±0.2×10 7 T2D vs. 0.6±0.1×10 7 controls, EPR a.u.; P <0.05). Baseline total ROS demonstrated a significant inverse relationship with resting RoR (R 2 = 0.49; P <0.05) as well as the percent change in RoR from rest to handgrip (R 2 = 0.34; P <0.05) with the latter relationship being strongest in T2D (R 2 = 0.77; P <0.05). These preliminary findings suggest that a greater underlying oxidative stress may contribute to impairments in CA in T2D at rest and during exercise.