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Smaller cerebrovascular arteries have a greater age‐related endothelial dysfunction and a blunted response to life‐long caloric restriction
Author(s) -
Walker Ashley E,
McCullagh Joesph P,
Lesniewski Lisa A,
Donato Anthony J
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.685.31
Subject(s) - medicine , cerebral arteries , endocrinology , middle cerebral artery , carotid arteries , nitric oxide , endothelial dysfunction , endothelium , artery , cardiology , ischemia
Life‐long caloric restriction (CR) protects against age‐associated diseases, but its effect on cerebrovascular arteries of varying size is unknown. We measured ex vivo endothelium‐dependent dilation (EDD, response to acetylcholine [ACh]) of larger (carotid) and smaller (middle cerebral artery [MCA]) arteries from young (Y‐AL, 6 mo, n=12) and old (O‐AL, 29–31 mo, n=12) ad libitum fed and old CR (O‐CR, 29–31 mo, n=19, 40%0.05). TEMPOL (superoxide dismutase mimetic) restored carotid artery EDD in O‐AL (91±3%, P<0.05), but had no effect in Y‐AL and O‐CR (P>0.05). In the MCA, TEMPOL restored EDD partially in O‐AL (43±16%, P<0.05), but diminished ACh‐induced dilation in O‐CR and Y‐AL (P<0.05). Thus, smaller cerebrovascular arteries have a greater age‐related reduction in endothelial function. Life‐long CR preserves endothelial function with age in larger arteries, but this response is blunted in smaller cerebrovascular arteries. Supported by AG029337 , AG040297 , AG033196