Premium
Aerobic Training (T) Improves Cerebral Circulation of Normotensive (WKY) and Spontaneously Hypertensive Rats (SHR)
Author(s) -
Jordão Maria Tereza,
Cavalleri Marina Tuppy,
Burgi Katia,
Ceroni Alexandre,
Michelini Lisete Compagno
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.685.18
Subject(s) - medicine , microcirculation , lumen (anatomy) , cerebral arteries , perfusion , cerebral circulation , hemodynamics , endocrinology , cardiology , anatomy , anesthesia
We compared the effects of hypertension and T in brain macro and microcirculation. Rats were submitted to treadmill T (55% of maximum capacity, 1h/day, 5 d/week) or kept sedentary (S) for 3 months. After hemodynamic measurements at rest, rats were anesthetized for iv . administration of FITC‐dextran (capillary density) or 4% PFA perfusion (morphometry of cerebral arteries). Brains were removed, post‐fixed and sliced for analysis of the capillary density within the NTS (25 μm) and of the basilar (BA), middle (MCA) and posterior cerebral (PCA) arteries (10 μm) (Image ProPlus). Compared to WKY, SHR exhibited elevated MAP and HR (180±2 mmHg, 359±6 b/min), increased wall/lumen ratio (+40%, +100% and +80% for BA, MCA and PCA, respectively), but no NTS capillary rarefaction. T was equally effective to improve treadmill performance and to cause resting bradycardia (−9%) in both groups; pressure fall (−8%) was only observed in the SHR. T reduced wall/lumen ratio only in the SHR (BA= −40%, MCA= −47%; PCA= −37%) and caused marked increase in capillary density in medial, intermediate and commissural NTS in both groups (on average 7.05 ±0.18 and 7.07±0.88%, corresponding to changes of +55% and +43%, WKY and SHR, respectively). Data showed that T improves brain perfusion by causing eutrophic outward remodeling in SHR brain arteries and capillary angiogenesis in both groups. Financial Support: CAPES, FAPESP