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Ventral and Dorsal Hippocampus of rats similarly modulate autonomic responses evoked by restraint stress
Author(s) -
Scopinho América Augusto,
Lisboa Sabrina F,
Corrêa Fernando M.A.,
Guimarães Francisco S,
Resstel Leonardo B.M.,
Joca Sâmia R.L.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.684.7
Subject(s) - microinjection , microinjections , endocrinology , medicine , heart rate , hippocampus , stimulation , dorsum , autonomic nervous system , anesthesia , blood pressure , chemistry , anatomy
The hippocampus is a brain structure divided into dorsal (DH) and ventral (VH) portions. Stimulation of these areas evokes autonomic changes. During restrain stress (RS) hippocampus neurons are activated, besides causing hormonal changes and autonomic responses such as increased heart rate (HR) mean arterial pressure (MAP) and reduction of tail temperature. Thus, the aim of our study was to investigate the involvement of VH and DH on the autonomic responses, caused by the RS. Methods Microinjections of CoCl 2 (cobalt chloride; 1mM/ 500nL) or vehicle in the VH or DH of Male Wistar were made. Ten minutes after the microinjection of drugs, the animals were submitted to the RS for an hour. During RS cardiovascular parameters and skin temperature were registered. Results The injections of CoCl 2 into the VH (n=6) significantly reduced the increase of both MAP (F 1,480 =449.5; P < 0.001) and HR (F 1,480 = 429.8, P<0.0001) and temperature decreases (F 1,144 = 273.2, P<0.0001) evoked by RS, when compared to the control animals (n=4). In the same way, the bilateral microinjections of CoCl 2 in DH (n=7) reduced the increase of both MAP (F 1,165 = 211, P<0.05) and HR (F 1,165 = 161, P<0.05) and temperature decreases (F 1,165 = 164, P<0.05) when compared to the control animals (n=6). Conclusion These results suggest that show that VH and DH similarly modulate autonomic responses to RS. Financial Support: CAPES and FAPESP.