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A novel telemeter for chronic measurement of arterial blood pressure or ECG in mice
Author(s) -
Lim Matthew,
Russell David,
Pauly Bob,
McCormick Daniel,
Kirton Robert,
Kondo Masahiro,
Guild Sarah-Jane,
Malpas Simon,
Budgett David
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.684.28
Subject(s) - telemetry , biomedical engineering , high fidelity , arterial catheter , blood pressure , medicine , computer science , electrical engineering , telecommunications , engineering
Currently telemetry devices for recording of physiological signals in mice are restricted by the relatively short battery life necessitating expensive exchange. We have developed a fully implantable telemetry system for high fidelity measurement of arterial pressure or ECG in mice. For recording arterial pressure the system incorporates a 1Fr micro‐tip solid state pressure catheter (diameter 0.3 mm) developed specifically for this device. The telemeter is continuously powered by a magnetic field, eliminating the requirement for a battery and thus allowing for potentially lifetime implantation and telemeter reuse. Data is sampled at 2 kHz enabling high fidelity recordings of arterial or ECG waveforms. Such high frequency sampling is particularly relevant for the analysis of ECG parameters. The system function was validated by implantation into mice, 25 gm or larger, and recording data for up to one month. The system developed is suitable for making arterial pressure measurements from mice, and could expand the scope of chronic monitoring.