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Impaired Baroreflex Sensitivity in Anabolic Steroid Users
Author(s) -
Santos Marcelo Rodrigues,
Porello Rafael Armani,
Sayegh Ana L C,
Hong Valeria,
Toschi-Dias Edgar,
Bortolotto Luiz A,
Yonamine Mauricio,
Negrao Carlos E,
Alves Maria-Janieire N N
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.684.27
Subject(s) - blood pressure , medicine , baroreflex , anabolism , heart rate , anabolic steroid , cardiology , endocrinology , diastole
Purpose Exacerbated sympathetic nerve activity and increased blood pressure have been documented in anabolic androgenic steroid users (AASU). We tested the hypothesis that arterial baroreflex sensitivity (BRS) and carotid distensibility would be reduced in AASU. Methods Ten AASU and 10 age‐paired anabolic androgenic steroid nonusers (AASNU) were studied. Both groups were involved in strength training (90% 1MR) and AASU were self‐administered anabolic steroids for at least 2 years. The use of AAS was proved by urine. Heart rate (HR) was evaluated by EKG and blood pressure non‐invasively on a beat to beat. BRS was analyzed by time domain through spontaneous fluctuations between systolic blood pressure (SBP) and HR. Carotid artery distensibility was measured by doppler (M‐mode). Results HR was higher in AASU compared to AASNU (69±3 vs. 59±3 bpm, P≤0.05). Systolic (123±4 vs. 118±2 mmHg, P=0.29), diastolic (72±2 vs. 67±2 mmHg, P=0.12) and mean blood pressure (90±3 vs. 85±2 mmHg, P=0.15) were not different between groups. BRS for increases (14.2±2 vs. 22.8±3 msec/mmHg, P=0.05) and decreases (13.3±1 vs. 19.2±2 msec/mmHg, P=0.04) were lower in AASU. Carotid distensibility was reduced in AASU (7±1 vs. 9±1 %, P≤0.05). Conclusion Impaired BRS and reduced carotid distensibility may prematurely lead to increased cardiovascular risk in AASU.