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Variation in kidney oxygenation: towards long‐term recording by telemetry
Author(s) -
Koeners Maarten,
Ow Pei,
Abdelkader Amany,
Papazova Diana,
Verhaar Marianne C.,
Evans Roger G.,
Russell David M.,
Joles Jaap A.,
Malpas Simon
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.684.2
Subject(s) - oxygenation , telemetry , ischemia , oxygen , kidney , perfusion , medicine , cardiology , anesthesia , chemistry , computer science , telecommunications , organic chemistry
Recently we developed a telemetry‐based carbon paste oxygen electrode (CPE) which can record kidney oxygenation in rats, unhindered by anesthesia or restraint. To test this new modality we first measured renal oxygen in anesthetised control and subtotaly nephrectomized (SNx) rats while varying inspired oxygen. Second, renal oxygen was measured before, during and after ischemia induced by a vascular clamp. Third, a fully implantable telemetry system was used for recording 3 weeks before and 1 day after ischemia. The CPE could easily detect changes in renal oxygen upon step‐wise increments and decrements of inspired oxygen, while renal perfusion pressure and blood flow remained unchanged from baseline. Kidney oxygenation was lower and less responsive to changes in inspired oxygen in SNx compared to controls. Telemetry‐based CPE could successfully measure renal oxygen before, during and after ischemia. Realisation of a telemetry‐based oxygen sensor, capable of long‐term monitoring of relevant perturbations, will enable us to elucidate links between renal oxygenation and kidney health. EU, FP7, Marie Curie Actions, International Outgoing Fellowship.