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Water drinking‐induced pressor response in sinoaortic denervated rats
Author(s) -
Abe Chikara,
Iwata Chihiro,
Morita Hironobu
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.684.10
Subject(s) - efferent , baroreflex , pressor response , blood pressure , anesthesia , medicine , endocrinology , chemistry , afferent , heart rate
Arterial baroreflex is well known to have a significant role in arterial pressure (AP) regulation upon acute disturbance for AP. Previous study from our laboratory demonstrated that AP was well maintained during rear‐up, if the baroreflex operated, but AP decreased by 15 ± 1 mmHg in sinoaortic denervated (SAD) rats. However, the different AP response was observed during rear‐up behavior with water drinking: i.e., the AP increased by 60 ± 5 mmHg in SAD rats. In order to clarify this mechanism, we examined the both afferent and efferent pathways in this response with SAD rats. For the efferent pathway, the pressor response was completely abolished by prazosin administration. However, for the afferent pathway, the pressor response was not suppressed by denervation of oral cavity, pharynx, or esophagus. However, magnitude of pressor response depends on the water infusion velocity via the oral tube. Furthermore, powder food feeding‐induced pressor response was significantly larger than solid food feeding. Accordingly, it is possible that the motor behavior such as swallowing might participate in the pressor response.