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Effect of aerobic exercise on capillary and vascular endothelial growth factor in rat soleus muscle
Author(s) -
Murakami Shinichiro,
Fujita Naoto,
Kondo Hiroyo,
Tanaka Masayuki,
Sakita Masahiro,
Fujino Hidemi
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.683.7
Subject(s) - soleus muscle , aerobic exercise , skeletal muscle , medicine , endocrinology , christian ministry , capillary action , chemistry , vascular endothelial growth factor , endurance training , vegf receptors , materials science , composite material , philosophy , theology
Aerobic exercise has been known an effective therapy against the muscle endurance fitness. And skeletal muscle is classified into 2 types, slow or fast muscle. Slow muscles have rich oxidative utilization and rich capillaries. And rat soleus muscle is a slow muscle. PURPOSE To clarify the effect of aerobic training exercise on capillary architecture in slow muscle, the 3‐D capillarity has been investigated. METHODS Wistar rat (Con) rats and age matched Wistar rat that performed aerobic exercise preconditioning for 3 weeks (EX) were used. Contrast medium‐injected capillary in soleus muscle was visualized using a confocal laser microscope. And vascular endothelial growth factor (VEGF) expression was measured. RESULTS VEGF expression in EX was significantly higher than that in Con. Number of capillaries and number of anastomoses in EX were increased than Con. Capillary diameter in soleus of EX rat was thicker than that of Con. And mean capillary volume in EX was significantly higher than that in Con. CONCLUSION Results of present study indicate that aerobic training builds capillarity architecture in soleus muscle more closely. This study was supported by Grantsin‐ Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology no. 23650340, 23650324, 23700600, 23700932 and 22300189.