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Thrombotic and thrombolytic factors in human plasma with aging
Author(s) -
Field Kristina A.,
Murray Erin Patrick,
Field Margaret F.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.681.15
Subject(s) - fibrinogen , medicine , plasminogen activator , antithrombin , tissue plasminogen activator , menopause , factor vii , endocrinology , population , risk factor , coagulation , heparin , environmental health
Increasing thrombotic disease is seen in the aging population, with reported differences by sex. This study sought to examine thrombotic and thrombolytic factors in human plasma while controlling for age and sex. Subjects ranged from 25–69 yr of age. Thrombotic factors; Fibrinogen (Fb), Factor VII (FVII), Factor X (FX), Tissue Plasminogen Activator Inhibitor (TPA‐I)) and thrombolytic factors; Tissue Plasminogen Activator (TPA) and Antithrombin III (ATIII) were analyzed using sandwich ELISA. Our results show a significant increase in FVII with age in women, with no difference in males. TPA‐I rises in females at perimenopause and remains elevated in menopause. Fb in males is significantly elevated in youngest and oldest groups. TPA‐I was markedly increased in the youngest males only. FX showed a sharp and linear decrease with age in males but not females. We conclude that the rise in clotting factors, Fb in males and FVII and TPA‐I in females may influence increased thromboembolic disease with aging. FX findings suggest that not all factors that are thrombotic play a role in increased thromboembolic disease with aging. The two thrombolytic factors had no significant variation in any experimental group. This research was supported by the Saint Mary's College of California Faculty‐Alumni Grant, Faculty Development Grant, and the Summer Research Program.