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Suppression of paclitaxel (PAC)‐induced neuropathic pain by hyperbaric oxygen (HBO 2 )
Author(s) -
Zhang Yangmiao,
Gibbons Carlee R.,
Howlader Saad,
Son Myngoc Chung,
Yeon Jiwoong,
Shirachi Donald Y,
Quock Raymond M.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.662.9
Subject(s) - medicine , neuropathic pain , anesthesia , hyperbaric oxygen , allodynia , nociception , pain relief , hyperalgesia , receptor
HBO 2 produces relief of acute pain (Chung et al., J. Pain 11:847, 2010). Recent studies have shown that HBO 2 can also relieve chronic pain (Thompson et al., Neurosci. Res. 66:279, 2010; Li et al., Anesth. Analg. 113:626, 2011). The aim of this study was to ascertain whether relief of neuropathic pain could be enhanced by increasing the number of HBO 2 treatments. Male Sprague Dawley rats were injected i.p. with either vehicle or PAC (1.0 mg/kg) on days 0, 2, 4 and 6 (cumulative dose 4 mg/kg). Twenty‐four hr after the last injection, rats were treated with 60‐min room air or HBO 2 at 3.5 ATA for either one or four days. Mechanical thresholds were assessed with an electronic von Frey anesthesiometer. PAC‐treated rats showed an allodynia that persisted for more than 30 days after the initial injection. Rats that underwent a single 60‐min HBO 2 treatment at 3.5 ATA on day 7 exhibited a recovery of the threshold after 3 weeks. However, rats that underwent four 60‐min HBO 2 treatments from days 7 thru 10 recovered approximately 7 days earlier than the rats with a single treatment. It is concluded that HBO 2 treatment is capable of causing dose‐dependent relief of PAC‐induced neuropathic pain. (This research was supported by NIH Grant GM‐77153 and the Allen I. White Distinguished Professorship.)