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Clinical and Biological Significance of KISS1 Expression in Prostate Cancer
Author(s) -
Wang Honghe,
Jones Jacqueline,
He Qinghua P.,
Grizzle William E.,
Welch Danny,
Turner Timothy,
Yates Clayton
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.657.12
Subject(s) - prostate cancer , malignancy , motility , metastasis , cancer research , clinical significance , medicine , metastasis suppressor gene , cancer , biomarker , cancer cell , suppressor , oncology , biology , microbiology and biotechnology , biochemistry
For men in the United States, prostate cancer (PCa) is the most frequent malignancy and the second leading cause of cancer mortality. The metastatic spread of PCs is responsible for most PCa–related deaths. Although KISS1 functions as a metastasis‐suppressor in various cancers, its expression and functions in PCa development and progression remain undetermined. The goals of this study were to correlate the expressions of KISS1 in PCas with clinicopathological characteristics and to assess the biological relevance of KISS1 to the viability and motility of PCa cells. Strong KISS1 staining was detected in benign prostate tissues, but the staining was weaker in primary and metastatic PCas (p<0.001, t‐test). Furthermore, the low expression of KISS1 in PCas correlated with clinical stage (p<0.01) and with KISS1R expression (p<0.001). Over‐expression of full‐length KISS1 in low KISS1 expressing PC‐3M cells, but not KFMÄSS which lacks the secretion signal sequence, induced re‐sensitization of cells to anoikis, although it had no effect on cell proliferation or apoptosis. Over‐expression of KISS1 also suppressed steps in the metastatic cascade, including motility and invasiveness. Moreover, cells over‐expressing KISS1 demonstrated enhanced chemosensitivity. Collectively, our data suggest that KISS1 functions as a metastasis suppressor in PCas and may serve as a useful biomarker and a therapeutic target for PCas.