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Quantifying differences in local wall stress between carotid and femoral arteries
Author(s) -
Wang Roy,
Gleason Rudy L,
Brewster Luke Packard
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.656.9
Subject(s) - pulsatile flow , biomechanics , carotid arteries , arterial wall , medicine , anatomy , femoral artery , biomedical engineering , cardiology , materials science
Objective Arterial remodeling after vascular procedures are mediated by pulsatile stress, but arterial wall biomechanics likely contribute; this study defines differences in arterial wall stress between healthy femoral and carotid arteries. Method Healthy nonhuman primate arteries were tested on a custom‐made device to determine biaxial mechanical responses. A custom LABVIEW program was using for data acquisition and processing. Local wall stress was calculated based on a nonlinear, finite deformation framework utilizing an orthotropic material model. Residual stresses were considered in the analysis through quantifying circumferential and longitudinal opening angles. Heteroscedastic t‐tests were used to analyze the results. Results The pressure‐diameter response of the arteries at the in vivo stretch demonstrate that femoral are stiffer than the carotid arteries (P=0.05); Fig. 1. Circumferential opening angle results (Fig. 2) also show a trend toward a greater opening angle in the femoral arteries (P=0.3). Conclusions These results support baseline biomechanical differences between femoral and carotid arteries in nonhuman primates. A better understanding of the matricellular differences between arteries may provide improved compatibility strategies for future therapies. (RLG:GTEC Foundation Endowment; NIH, NSF)