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Genetic variation in CARD15 and allergy
Author(s) -
Katenta Anna,
Guerra Stefano
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.656.6
Subject(s) - atopy , single nucleotide polymorphism , asthma , allergy , snp , medicine , immunology , genetic association , biology , genetics , genotype , gene
Caspase‐recruitment domain containing protein 15 (CARD15) functions as a cytosolic receptor involved in bacterial recognition by antigen‐presenting cells. It was hypothesized that through the use of data analysis and statistical software, CARD15 polymorphisms would be determined to have significant association with asthma and atopy‐related phenotypes, using a large Tucson‐based cohort. Five Single Nucleotide Polymorphisms (SNPs) were genotyped in CARD15 and the Hardy‐Weinberg equilibrium (HWE) was evaluated. Chi square tests were run for each SNP that passed HWE using the following variables: ever asthma, allergic rhinitis, ever atopy. Statistical significance for associations with asthma, allergic rhinitis, and atopy was set at p < 0.05. Our results suggest that there is no association between the SNPs RS2066842 and RS5743291 with asthma and allergic rhinitis. However there is a possibility that these SNPs may be associated with atopy. These results need to be replicated in other populations to reduce the risk of spurious results. In the future, if SNPs RS2066842 and RS5743291 are confirmed to have significant association with atopy, patients can be screened for them and their risk of developing atopy can be determined.