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Serum inosine, and symmetrical di‐methyl arginine (SDMA) concentrations were reduced at different time points when dogs were fed a controlled protein and phosphorus food with different fatty acid compositions
Author(s) -
Jewell Dennis Edward,
Yerramilli Maha,
Obare Edward,
Yerramilli Murthy
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.651.12
Subject(s) - inosine , chemistry , nefa , urea , composition (language) , zoology , fish oil , albumin , fatty acid , uric acid , food science , serum albumin , biochemistry , medicine , endocrinology , biology , fish <actinopterygii> , adenosine , linguistics , philosophy , fishery
Dogs (43, 3.1 to 14.8 years of age) were assigned to one of three dietary treatment foods which was fed throughout the experiment in order to evaluate the effect of food on specific circulating metabolites. Dogs were analyzed for body composition and serum analyzed at 0, 1, 3 and 6 months. Serum analysis included urea, albumin, fatty acids, inosine and SDMA. The experimental protocol was reviewed and approved by the Institutional Animal Care and Use Committee. All foods contained approximately 14% protein and 18% fat. Fatty acid composition was as follows:Food 12:0 18:2
n6 18:3
n3 20:5
n3 22:6
n3 Control (C) 0.01 3.07 1.27 0.01 0.0 C + fish oil (CFO) 0.01 3.09 1.35 0.10 0.07 CFO + coconut oil (CFOCO) 0.87 4.61 1.63 0.23 0.17Serum fatty acid concentration increased in response to increased intake throughout the study. There was no change in albumin concentration or lean body mass. There was a decrease in serum urea nitrogen and inosine after one month and through the rest of the study (P<0.05). There was no change in SDMA at one month but a significant decrease (P<0.05) through the rest of the study. The finding that SDMA was not different at one month while urea, inosine and the fatty acids mentioned above were all changed suggests that SDMA was controlled through a different function, reflecting an adaption to the dietary intake rather than a mass action response. This research was supported by Hill's Pet Nutrition and IDEXX Laboratories.