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Omeprazol produces changes in blood calcium, phosphorous and magnesium after food ingestion in horses
Author(s) -
Manso-Filho Hélio Cordeiro,
Manso Helena Emília Cavalcanti C C,
Mélo Stephânia,
Lima Rebeca,
DˈAraújo Juliana,
Almeida Telga,
Silva Flávia Souza e,
Cortizo Julianne,
DˈPaula Joyci,
Wanderley Erika,
Hunka Monica
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.650.1
Subject(s) - ingestion , latin square , blood calcium , calcium , zoology , bolus (digestion) , magnesium , medicine , chemistry , endocrinology , biology , biochemistry , rumen , organic chemistry , fermentation
Omeprazol (OMPZ) is used to prevent gastric ulcer syndrome in athletic horses. The aim of this research was to characterize changes in blood [Ca++], [P‐] and [Mg++] in ulcer‐free horses after omeprazol treatment. A Latin square design, with four horses and four treatments (T1: control, T2: 4mg/kg PO bolus treatment, T3: 1mg/kg PO during 11 days and T4: 4mg/kg PO during 11 days) was used. Blood was collected during fasting and 0.5h through 7.0h after feeding. Data were analyzed by two‐way ANOVA. It was observed decrease in [P] between treatments (P<0.05) but not change in [Ca] or [Mg] (P>0.05). Similarly, only [P] showed a significant difference between the phases of blood collection (P<0.05). There were no interactions between the phases of blood collection and treatments (P>0.05). These results demonstrated that OMPZ, which reduces pH of stomach, changed absorption of dietary P, reducing the serum concentration (T1: ~3,4mg/mL; T2: ~3,6mg/mL; T3: ~2,6mg/mL; T4: ~3,2mg/mL). In conclusion, treatment with OMPZ lowered serum [P] but not [Ca] or [Mg] in healthy horses. Changes in blood mineral parameters are important in athletic horses, which are undergo intense bone adaptation in response to exercise.