Premium
Effect of maternal diet on proliferation and development of rat offspring liver
Author(s) -
Kwon Young Hye,
Won Sae Bom,
Han Anna
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.648.6
Subject(s) - offspring , endocrinology , medicine , genistein , lactation , biology , casein , weaning , homocysteine , gestation , pregnancy , biochemistry , genetics
Several studies have suggested that nutrition during fetal and neonatal periods may affect liver development and function. We have reported that maternal consumption of either low‐isoflavone soy protein isolate (SPI) or genistein has profound and unique consequences to a programming of lipid metabolism in rat offspring. Therefore, we investigated effects of early life consumption of SPI and genistein on liver proliferation and development. Female rats were fed casein, low‐isoflavone SPI, or casein supplemented with genistein diet for two weeks before mating and throughout pregnancy and lactation. Male offspring were studied at 21 d after birth (CAS, SPI, and GEN groups). As determined by proliferation cell nuclear antigen protein and H19 mRNA levels, hepatic proliferation was higher in SPI group compared to CAS and GEN groups, which may contribute to increased relative liver weights. Consistently, we observed an increased activation of beta‐catenin pathway in SPI group. There was no difference in apoptosis among groups. Serum homocysteine levels were higher, and betaine‐homocysteine S‐ methyltransferase and glycine N ‐methyltransferase mRNA levels were lower in SPI group than those in CAS and GEN groups, suggesting that one‐carbon metabolism may be involved in maternal dietary regulation of liver proliferation and development in offspring. This work was supported by National Research Foundation of Korea.