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Dose response bioavailability of green tea catechins in humans
Author(s) -
Renouf Mathieu,
Guy Philippe,
Marmet Cynthia,
Giuffrida Francesca,
Dionisi Fabiola
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.646.4
Subject(s) - bioavailability , catechin , polyphenol , camellia sinensis , ingestion , chemistry , green tea , food science , green tea extract , oral dose , pharmacology , absorption (acoustics) , area under the curve , pharmacokinetics , medicine , botany , biochemistry , antioxidant , biology , physics , acoustics
Tea is an infusion of the leaves of the Camellia sinensis plant and is the most widely consumed beverage in the world after water. Because the bioavailability of green tea catechins appears to be simpler than other polyphenols, studies on catechin bioavailability have provided precise data. However, not all is known on this topic. We investigated dose response plasma appearance of catechins after ingestion of increasing doses of commercially available infused green tea by 10 healthy volunteers. Regardless of the dose, EGC and EC were the most abundant plasmatic metabolites. Area under the curve (AUC) of EGCg and EC increased with the ingested dose of the beverage. On the other hand, the AUC of EGC and 4‐O‐Me‐EGC showed a dose response effect between the low and medium dose ingested, but saturation occurred between the medium and high doses drunk. Finally the AUC of ECg decreased with the ingested dose. The same findings were observed for C max . While the sum of AUC per dose showed an overall saturation effect between the medium and high dose of green tea ingested, one should be careful in interpreting the data, as the pattern of individual catechins absorption differs from one another.