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Anthocyanin Metabolites in the Mice Fed Purple‐fleshed Anthocyanin‐enriched Sweetpotato
Author(s) -
chen Tzu-yu,
xu jianteng,
Lim Soyoung,
Carey Edward,
Katz Ben,
Griffin Jason,
John Tomich,
Wang Weiqun
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.646.2
Subject(s) - anthocyanin , peonidin , food science , bioavailability , chemistry , azoxymethane , pigment , biology , botany , cyanidin , biochemistry , pharmacology , gene , delphinidin , carcinogenesis , organic chemistry
Anthocyanins are plant pigments that are epidemiologically associated with reduced chronic diseases including cancer. We previously selected a purple‐fleshed sweetpotato P40 clone that enriched a high content of anthocyanins up to 7.5 mg/g dry matter. We demonstrated that dietary P40 might prevent colorectal cancer in azoxymethane‐induced murine model. This study is to detect the potential anthocyanin metabolites in this animal model. CF‐1 mice were fed 10~30% of P40 containing 143~430 mg peonidin‐3‐glucoside equivalence/kg B.W. for 6 wks and then anthocyanin metabolites were analyzed by LC/MS and MALDI. Although anthocyanin metabolites in both plasma and liver tissues were not detectable 15‐hrs after the last feeding, four anthocyanin metabolites were identified in the feces, including cyaniding‐3,5‐diglucoside, cyaniding‐3‐p‐hydroxybenzoylsophroside‐5‐glucoside, cyaniding‐3‐sophoroside‐5‐glucoside, and peonidin‐3‐p‐hydroxybenzoylsophroside‐5‐glucoside. Better understanding of anthocyanin metabolism and bioavailability may lead the development of a functional purple‐fleshed anthocyanin‐enriched sweetpotato for health benefits.