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Effects of whole grain phytochemicals on biomarkers of postprandial metabolic dysregulation in overweight/obese adults following an oral glucose challenge
Author(s) -
McKay Diane L.,
Chen C-Y. Oliver,
Blumberg Jeffrey B.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.646.12
Subject(s) - postprandial , crossover study , overweight , meal , medicine , insulin , leptin , whole wheat , adiponectin , obesity , food science , zoology , placebo , insulin resistance , endocrinology , biology , alternative medicine , pathology
The phytochemicals of whole grains may contribute substantially to their health benefits, but studies examining their bioactivity in humans are limited. To determine the degree to which whole grain oat and barley phytochemicals affect postprandial glucoregulation and inflammation, we conducted a controlled, 3‐way crossover trial in 13 healthy subjects, age 40–70 y with BMI 27–35.9. After a 2‐d run‐in period following a diet low in phytochemicals, subjects were randomized to receive muffins made with 48 g whole oat, barley, or refined wheat flour + fiber (control), with a 1 wk washout period between each intervention. Blood and urine samples were collected at specified time points before and for 3 h following the consumption of each test muffin concomitant with a 75 g glucose bolus to perturb homeostasis. Biomarkers of glucoregulation were better controlled with barley and oats compared to the control (Matsuda index: oats>barley>control; HOMA‐IR: oats