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Maternal DHA Supplementation Improves Lung Growth and Function in Offspring Exposed to LPS and Hyperoxia
Author(s) -
Velten Markus,
Heyob Kathryn M,
Britt Rodney D,
Valentine Christina J,
Tipple Trent E,
Rogers Lynette K
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.644.15
Subject(s) - offspring , hyperoxia , saline , medicine , inflammation , lung , pregnancy , endocrinology , physiology , gestation , birth weight , respiratory system , biology , genetics
Background Maternal inflammation contributes to low birth weight and preterm delivery. Premature infants routinely receive therapeutic oxygen and exhibit persistently diminished respiratory function into adulthood. Objective We tested the hypothesis that DHA supplementation reduces the detrimental effects of a hostile perinatal environment. Methods Pregnant C3H/HeN mice were fed DHA or control diet (CD) and injected with LPS or saline on embryonic day (E) 16. Offspring were placed in room air (RA) or 85% O2 for 14 d then returned to RA. PFTs, microCTs, molecular, and histological analyses were performed. Main Results Birth weight was reduced in pups born to CD/LPS dams but not different than controls in the pups born to DHA/LPS dams. At 8 weeks of age, bodyweights were lower, the lungs had fewer and larger alveoli, and static compliance was decreased in mice born to dams fed CD and exposed to LPS/O2. Maternal dietary supplementation with DHA in LPS/O2 exposed mice reversed these effects even at 8 weeks with bodyweights, alveolarization, and PFT measurements in not different than CD or DHA diet, saline injected, RA exposed controls. Conclusions The detrimental effects of systemic maternal inflammation and neonatal hyperoxia exposure on offspring lung structure and function in adulthood can be reduced by maternal DHA supplementation.