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Predictors of 5‐year change in plasma 25‐hydroxyvitamin D (25(OH)D) concentrations in postmenopausal women
Author(s) -
Kluczynski Melissa,
Platek Mary,
DeNysschen Carol,
Wactawski-Wende Jean,
Millen Amy
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.643.1
Subject(s) - vitamin d and neurology , medicine , body mass index , postmenopausal women , baseline (sea) , vitamin d deficiency , endocrinology , biology , fishery
Objective Determine the predictors of 5‐year change in Δ 25(OH)D concentrations. Methods Postmenopausal women in the Osteoporosis and Periodontal Disease Study (N=668) had 25(OH)D assessments at baseline (1997–2000) and 5‐years (2002–2005). Baseline and Δ dietary, lifestyle and health‐related factors were tested as predictors using linear regression. Results The mean increase in 25(OH)D was 7.7 nmol/L (SD=0.7, P<0.001). Predictors explained 31% of the variance in Δ 25(OH)D and included baseline 25(OH)D, baseline and Δ vitamin D supplement intake and physical activity, Δ season of blood draw, Δ body mass index, Δ whole body T‐score, and baseline hormone use. Baseline 25(OH)D and Δ vitamin D supplement intake explained the most variance (25%) in 25(OH)D. In exploratory analyses, there was a borderline significant interaction between baseline 25(OH)D and Δ vitamin D supplement use after adjustment for predictors of Δ 25(OH)D (P=0.063). The greatest increase in 25(OH)D occurred in women in the lowest tertile of baseline 25(OH)D who increased supplement intake from baseline to follow‐up. Conclusions Baseline 25(OH)D and Δ vitamin D supplement intake were most predictive of increasing 25(OH)D. Increasing 25(OH)D through supplementation depends on initial 25(OH)D.