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Reduced Sampling Schedules for Calculation of an Insulin Sensitivity Index from the Liquid Meal Tolerance Test
Author(s) -
Maki Kevin C,
Gower Barbara A.,
Rains Tia M.,
Schild Arianne
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.638.12
Subject(s) - meal , zoology , correlation coefficient , medicine , population , insulin , correlation , insulin sensitivity , mathematics , endocrinology , statistics , insulin resistance , biology , geometry , environmental health
Previous results from our laboratory indicate the Matsuda insulin sensitivity index (MISI) calculated from a liquid meal tolerance test (LMTT) correlates well with the minimal model insulin sensitivity index (S I ). The present analysis evaluated the influence of reduced LMTT sampling schedules on the relationship between MISI and S I. Subjects included 38 men and 31 women, mean±SEM age 35.1±1.0 yr and BMI 32.5±0.5 kg/m 2 . For the LMTT, subjects consumed a liquid meal (Carnation Instant Breakfast ® and whole milk) providing 7 kcal/kg (24% fat, 59% carbohydrate, and 17% protein). S I was calculated from the 30‐ sample, insulin‐modified intravenous glucose tolerance test (MINMOD, v3). The Pearson correlation coefficient between S I and the MISI using values at 0, 30, 60, 90, 120 min was 0.519, p<0.0001. Correlation coefficients for selected reduced sampling schedules were: 0, 60, 120 min (r=0.493); 0, 120 min (r=0.534); 0, 30, 120 min (r=0.476); 0, 30, 60 min (r=0.450), 0, 60 min (r=0.461; all comparisons p<0.001). Correlation coefficients for the full and reduced schedule MISI values were r=0.953 for the 0, 60, 120 min and r=0.909 for the 0, 120 min schedules, respectively (both p≤0.0001). These results suggest that the MISI calculated from reduced sampling schedules (0, 60, 120 min and 0, 120 min) may be useful for application in population studies.