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In utero bisphenol A exposure: Effects on metabolic homeostasis throughout the life‐course
Author(s) -
Anderson Olivia S,
Sanchez Brisa N,
Peterson Karen E,
Zhang Zhenzhen,
Dolinoy Dana C
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.637.5
Subject(s) - offspring , in utero , endocrinology , medicine , population , litter , biology , pregnancy , fetus , genetics , environmental health , agronomy
Animal studies have linked in utero and early postnatal bisphenol A (BPA) exposure to increased body weight but controversy exists about BPA's role as an obesogen given evidence for its effect on spontaneous behavior and cognitive function in absence of altered body weight. Utilizing isogenic a/a mice, we examined effects of in utero exposure of 50 ng (n=20), 50 ug (n=21), or 50 mg (n=18) of BPA/kg diet on offspring energy expenditure, activity, and body composition at 3, 6, and 9 mo of age using linear mixed regression adjusting for sex and light cycle. Results indicate that mg offspring had higher oxygen consumption at 3 mo (p=0.002) as well as ng female offspring at 9 mo (p=0.05) compared to control offspring (n=19). In females, ambulatory activity was increased in mg offspring at 9 mo (p=0.002), ug offspring at 3 and 9 mo (p=0.001 and 0.02), and ng offspring at 3 mo (p=0.02). Vertical activity was increased in mg offspring at 3 mo and in females at 9 mo (p=0.0006 and 0.02), and in ug offspring at 9 mo among females (p=0.003). Also, ng and ug offspring display marginally significant decreases in fat percentage and body weight. Our life course analysis indicates BPA is associated with hyperactive and lean phenotypes in a/a mice, underscoring the need to evaluate the effects of early BPA exposure in human clinical and population studies. This work is supported by NIH grants DK089503 and ES017524 and NIH/EPA grant P20 ES01817101/RD834800.