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Soluble Receptor for Advanced Glycation Endproducts (sRAGE) Correlates Inversely with Body Mass Index (BMI) and Waist Circumference and Positively Correlates with High Molecular Weight Adiponectin
Author(s) -
Davis Kathleen E.,
Imrhan Victorine,
Prasad Chandan
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.637.12
Subject(s) - adiponectin , waist , medicine , body mass index , endocrinology , glycation , anthropometry , rage (emotion) , obesity , receptor , insulin resistance , biology , neuroscience
sRAGE acts as a decoy receptor for Advanced Glycation Endproducts (AGE), reducing concentrations of AGE in the blood and thus decreasing RAGE‐mediated inflammation. Factors affecting circulating sRAGE are not well defined. Anthropometrics were obtained from healthy adult participants (n=67). Serum was analyzed for sRAGE for all participants. Adiponectin, high molecular weight adiponectin, insulin, and cholesterol were also assessed (n=34). Factors inversely correlated to sRAGE include weight (−0.409; p=0.001), waist circumference (−0.337; p=0.005), and BMI (−0.402; p=0.001). High molecular weight adiponectin is positively correlated with sRAGE (0.406; p=0.02).