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Relationship of cognitive function with plasma homocysteine, folate, vitamin B12 levels and nutrient intake in cognitively impaired elderly
Author(s) -
Kim Ggotpin,
Kim Hyesook,
Kim Yoonsun,
Kim Hee Jung,
Son Jung In,
Kim Seong Yoon,
Chang Namsoo
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.627.1
Subject(s) - vitamin b12 , hyperhomocysteinemia , homocysteine , medicine , dementia , vitamin , endocrinology , b vitamins , physiology , disease
This study investigated the relationship of cognitive function with plasma homocysteine (Hcy), folate, vitamin B12 levels and nutrient intake. A total of 321 subjects, including 121 normal subjects, 100 each from mild cognitive impairment (MCI) and Alzheimerˈs disease (AD) patients participated in this study (age 60 yrs and over). Diagnostic assessments were administered using the Korean version of Consortium to Establish a Registry for Alzheimerˈs Disease. Dietary intake was assessed using 24‐hour recall. Mean plasma Hcy level was higher in AD and MCI compared to normal subjects. AD group also had higher proportion of hyperhomocysteinemia and folate deficiency. Plasma Hcy level was negatively correlated with plasma folate and vitamin B12 levels, total intake of vitamin B2, vitamin B6, folate, vitamin B12, vitamin C and vitamin E. Multiple regression analysis with covariates revealed that plasma Hcy level was negatively, whereas plasma folate level, total intake of vitamin B2, vitamin B6, folate, vitamin C, vitamin E and beta‐carotene were positively associated with cognitive function. The results suggest that plasma Hcy, B vitamins and antioxidants intake are associated with cognitive function, and plasma Hcy level is negatively correlated with B vitaminsˈ nutritional status and antioxidants intake. This work was supported by the Brain Korea 21 project.