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Reducing the glycemic load of mixed meals reduces postprandial glycemia and insulinemia over the entire day but does not affect satiety
Author(s) -
Liu Ann G,
Most Marlene M,
Brashear Meghan M,
Johnson William D,
Cefalu William T,
Greenway Frank L
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.626.4
Subject(s) - postprandial , glycemic index , glycemic load , medicine , endocrinology , glycemic , carbohydrate , insulin , overweight , area under the curve , crossover study , body mass index , placebo , alternative medicine , pathology
Low glycemic index/glycemic load diets may aid in body weight regulation through promotion of satiety. We evaluated the effects of mixed meals differing in glycemic index and carbohydrate content on postprandial serum glucose and insulin response, hunger and satiety over the course of a 12 hr day. In this randomized crossover trial, 26 overweight or obese adults received four diets in random order (HGI‐HC: high glycemic index, high carbohydrate; HGI‐LC: high glycemic index, low carbohydrate; LGI‐HC: low glycemic index, low carbohydrate; LGI‐LC: low glycemic index, low carbohydrate). Participants received breakfast, lunch, and dinner over the course of a 12 hr day. Primary outcomes were postprandial serum glucose and insulin quantified as area under the curve. Hunger, fullness, and satiety were assessed by visual analog scale. The HGI‐LC, LGI‐HC, and LGI‐LC diets significantly reduced glucose and insulin area under the curve compared to the HGI‐HC diet (P < 0.001 for all comparisons). There were no significant differences in ratings of hunger, fullness, or satiety between the different dietary treatments. Reducing the glycemic index or carbohydrate content of mixed meals is an effective method of controlling postprandial glycemia and insulinemia. This work was funded by General Mills.