Premium
Effects of Vitamin D and Calcium Supplementation on Blood Pressure and Serum Lipids: A Randomized, Double‐blind, Placebo‐controlled, Clinical Trial
Author(s) -
Chai Weiwen,
Bostick Roberd M,
Franke Adrian A,
Cooney Robert V
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.626.22
Subject(s) - calcium , blood pressure , placebo , medicine , vitamin d and neurology , endocrinology , vitamin , lipid profile , cholesterol , blood lipids , alternative medicine , pathology
Objective To estimate the effects of vitamin D +/− calcium supplementation on blood pressure and serum lipid levels. Methods Ninety‐two men and women (40 to 75 years) were randomized in a pilot, double‐blind, placebo‐controlled clinical trial of daily supplemental vitamin D 3 800 IU and calcium 2 g (as calcium carbonate) alone or in combination in divided doses twice daily with meals. Blood was drawn at baseline and after 6 months of intervention and stored serum samples were analyzed for serum total cholesterol and triglycerides. Systolic and diastolic blood pressures were also measured at baseline and at one and six months follow up. Results Relative to placebo, mean serum triglycerides decreased 30.1% (P = 0.20) and 32.1% (P = 0.18) in the calcium and calcium plus vitamin D 3 treated groups, respectively. Similar but non‐substantial decreases were observed for mean serum total cholesterol levels (calcium group, 5.3% lower, P = 0.31; calcium plus vitamin D 3 group, 6.8% lower, P = 0.19). In the intention‐to‐treat analyses there were no statistically significant changes in mean systolic and diastolic blood pressures in the calcium and vitamin D groups relative to the placebo group. Conclusions Supplemental vitamin D 3 and calcium may reduce serum lipid levels but have no substantial effects on blood pressure.