Premium
Grape seed extract attenuates oxidative stress induced by high fat/carbohydrate meal in metabolic syndrome patients
Author(s) -
Tadapaneni Ravi Kiran,
Krishnankutty Sandhya,
Alandete Lourdes,
Randolph Jody M.,
Cheema Mandeep,
Park Eunyoung,
Edirisinghe Indika,
Freeman Britt Burton,
Kappagoda C. Tissa
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.626.14
Subject(s) - postprandial , oxygen radical absorbance capacity , meal , oxidative stress , chemistry , food science , antioxidant , grape seed extract , carbohydrate , polyphenol , placebo , biochemistry , endocrinology , medicine , antioxidant capacity , diabetes mellitus , alternative medicine , pathology
Metabolic syndrome (MS) is associated with increased oxidative stress. Consumption of a high carbohydrate moderate fat (HCMF) meal results in increased markers of postprandial oxidative stress. We hypothesized that grape seed extract (GSE‐Meganatural © Gold), rich in antioxidants would attenuate HCMF meal‐induced oxidative stress in MS. After an overnight fast, 12 subjects with MS (6 men/6 women) consumed a HCMF meal in a randomized cross‐over design. A GSE (300 mg) or placebo capsule was administrated 1 h before the meal. Postprandial changes in plasma lipophilic (LA), hydrophilic (HA) antioxidant status (Oxygen Radical Absorbance Capacity‐ORAC) and oxidized LDL (OX‐LDL) were measured hourly for 6 h. Postprandial plasma ORAC values (LA and HA) measured as area under the curve over 6 hr were significantly increased when the meal was preceded by GSE compared with placebo (P<0.05). Meal‐induced increases in OX‐LDL were attenuated with GSE (P<0.05). These data suggest that the antioxidant activity of GSE produces favorable effects in attenuating oxidative stress in subjects with the MS. Funding: Polyphenolic Inc. Madera, CA