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Effect of dairy foods on cell adhesion molecules (CAMs)
Author(s) -
Hilpert Kirsten,
West Sheila G,
Ferencik Emily,
Bagshaw Debrah,
Kris-Etherton Penny M
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.626.11
Subject(s) - medicine , crossover study , endocrinology , zoology , chemistry , biology , alternative medicine , pathology , placebo
CAMs mediate atherosclerosis and thus are considered biomarkers of endothelial dysfunction. Elevated levels of CAMs predict heart disease risk and research has focused on strategies to lower them. Yet, studies of how diet affects CAMs are lacking. This study examined the effect of dairy foods on CAMs serum levels. Adults with untreated hypertension (n=23) were fed 3 experimental diets (5 wk each) in a randomized crossover study design. Diets included a dairy‐rich, high fruits and vegetables diet (D‐F&V; 30% fat, 7% saturated fat [SFA], 3.4 servings [svg]/d dairy, 9.6 svg/d F&V), a high fruits and vegetables diet (F&V; 30% fat, 7% SFA, 0.4 svg/d dairy, 9.6 svg/d F&V), and an average Western diet (AWD; 36% fat, 15% SFA, 0.4 svg/d dairy, 3.6 svg/d F&V). The D‐F&V diet reduced VCAM‐1 (547 ± 33 ng/mL) by about 16% compared with the F&V diet (649 ± 33 ng/mL, p < 0.05) and the AWD diet (650 ± 34 ng/mL, p < 0.05). Compared with the AWD diet, ICAM‐1 (242 ± 14 ng/mL) was significantly reduced by both the D‐F&V (225 ± 14 ng/mL, p < 0.05) and F&V diets (226 ± 14 ng/mL, p < 0.05). E‐selectin and P‐selectin followed a similar pattern, with the D‐F&V diet eliciting the lowest levels (D‐F&V vs. AWD, p < 0.02; D‐F&V vs. F&V, p < 0.1; F&V vs. AWD, p=ns). Collectively, these results suggest that dairy foods may have beneficial effects on endothelial function in hypertension. Funding: National Dairy Council, GCRC Penn State University NIH M01 RR10732