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A Mass Spectrometry Simulation for Biochemistry Education
Author(s) -
Fisher Amanda,
Craig Paul A.
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.579.2
Subject(s) - mass spectrometry , tandem , tandem mass spectrometry , computer science , spectrometer , fragment (logic) , chemistry , computational science , chromatography , physics , materials science , algorithm , quantum mechanics , composite material
The separations simulations team at RIT has been developing interactive simulations of biological separation processes for over 10 years. The JBioFramework collection of interactive simulations is now platform independent and runs equally well on all common operating systems. The updated 2D electrophoresis simulation utilizes multiple file types and Internet resources, and a new simulation has been added ‐ tandem mass spectrometry. The tandem MS simulation accepts data from the 2D electrophoresis simulation, allowing a student to select a protein from the gel and select a protease to digest it. Users can click on a peptide fragment on the first Mass Spectrometer readout, then see the b‐ and y‐fragments that give the peptide sequence in the second Mass Spectrometer readout. Support for this work has been provided by the RIT Colleges of Science and Computing and Information Science and by the Merck/AAAS Undergraduate Science Research Program.