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Association of apolipoprotein A5 gene ‐1131T>C polymorphism and metabolic syndrome in Korean subjects
Author(s) -
Song Kwang Hoon,
Yu Sung-Gon,
Yu Hyunjoo,
Kim Jong Yeol
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.570.4
Subject(s) - medicine , hypertriglyceridemia , metabolic syndrome , triglyceride , endocrinology , genotype , apolipoprotein b , biology , cholesterol , genetics , gene , obesity
The apolipoprotein A5, APOA5, genetic polymorphisms, ‐ 1131T>C ( rs662799 ) has been reported to be associated with hypertriglyceridemia that is one of the metabolic syndrome components. We assessed the association between the genetic polymorphism of APOA5 ‐1131T>C and lipid parameter and other risk factors of the metabolic syndrome in Korean subjects. A total of 2,683 participants from 20 oriental medical hospitals in Korea between 2006 and 2011 were enrolled. The APOA5 ‐ 1131T>C genotype was significantly associated with serum high‐density lipoprotein cholesterol levels (effect= −1.516 mg/dL, p = 6.414E‐06) in total study population after adjustment for differences in age and gender. The association of APOA5 ‐ 1131T>C with serum triglyceride was also significant in an additive genetic model (effect = 19.891 mg/dL, p = 3.876E‐17). Multiple logistic regression model adjusted for age and gender revealed that the subjects with CC genotype had an increased risk for metabolic syndrome (OR= 1.951, 95% CI=[1.443–2.637], P = 1.397E‐05). We demonstrated that APOA5 ‐1131T>C polymorphism was not only associated with serum high‐density lipoprotein cholesterol and triglyceride levels but also was associated with the metabolic syndrome as a result of its remarkable effect on serum triglyceride levels in Korean subjects in the current study.