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Adipocytokines as potential biomarkers for breast and prostate cancers
Author(s) -
ALOKAIL MAJED S,
Al-Daghri Nasser M,
Alkharfy KHALID M,
ALATAS OMAR S,
SABICO SHAUN,
DRAZ HOSSAM M
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.569.1
Subject(s) - prostate cancer , medicine , adipokine , breast cancer , adiponectin , prostate , endocrinology , cancer , oncology , obesity , leptin , insulin resistance
The link between obesity and premenopausal women breast cancer and prostate cancer development has been recently attributed. Hence, the purpose of this study is to pave a way for development of a blood based gene expression tests and clinical biochemical tests for early detection of breast cancer in obese premenopausal women and prostate cancer in obese men. Fasting blood samples were tested and serum adipocytokines and inflammatory markers were measured using multiplex assays. We have determined the mRNA gene expression quantity of adiponectin, prostate specific antigen (PSA), parathyroid hormone‐related peptide (PTHrP), interleukin‐6 (IL‐6), epidermal growth factor (EGF), erbB‐2, tumour growth factor‐beta (TGF‐ β ), tumor necrosis factor‐beta (TNF‐ β ) and P53 genes in 1000 samples of controls, breast and prostate cancer in male and female subjects. The results showed significantly increased in gene expression levels for P53, PTHrP and IL‐6, and significantly decreased levels of adiponectin were found in obese group, while the levels of TNF‐alpha and TGF‐alpha were unaltered. In conclusion, this study revealed strong positive relation of P53, PTHrP, and interleukin 6 with the obesity and breast and prostate cancers development. This relation raises several questions for further experimentation concerning their exact role and physiological significance.