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Effects of Ionizing Radiation on Mitochondria in Human Cell Lines
Author(s) -
Sweet Erik,
Kwiatkowski David,
Reynods Jacquelyn,
O'Donnell Robert,
Pogozelski Wendy
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.565.14
Subject(s) - ionizing radiation , human cell , mitochondrial dna , mitochondrion , non ionizing radiation , dna , biology , cell , cell culture , microbiology and biotechnology , genetics , physics , irradiation , gene , optics , nuclear physics
We have previously reported that levels of the common 4977‐bp deletion in human mitochondrial DNA increases when human cell lines are exposed to ionizing radiation. Here we expand these studies, using a variety of techniques to show the effects of ionizing radiation on mitochondrial DNA structure.