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Either Intravenous or Inhaled Anesthetic for Elective Otorhinological Surgery Does Not Induce Oxidative Stress
Author(s) -
Braz Mariana Gobbo,
Braz Leandro Gobbo,
Fecchio Denise,
Anjos Ferreira Ana Lucia,
Braz Jose Reinaldo Cerqueira,
Tang Guangwen,
Yeum Kyung-Jin,
Salvadori Daisy Maria Favero
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.541.2
Subject(s) - propofol , isoflurane , oxidative stress , anesthetic , medicine , anesthesia , antioxidant , pharmacology , chemistry , biochemistry
Oxidative status of patients undergoing surgery with either intravenous or inhaled anesthetics was studied. Thirty adult patients classified as physical status I, who were scheduled for otorhinological surgery, were randomized to receive propofol (n=15) or isoflurane (n=15) anesthesia. Blood samples were drawn before (T1) and 2 h after the beginning of anesthesia (T2) and on the following day of surgery (T3). Plasma pro‐inflammatory IL‐6 cytokine and apoptosis evaluated in T helper cells were detected by flow cytometry; oxidative DNA damage in lymphocyte by the comet assay; and antioxidant performance by fluorometry. IL‐6 increased in T3 for both groups. While propofol decreased oxidized purines in T2 compared to T1 (p=0.01), isoflurane did not induce oxidative DNA damage. Both anesthetics tend to increase antioxidant performance in T2 (p=0.06 for propofol and p=0.1 for isoflurane). Propofol decreased the frequency of apoptotic cells in T2 and T3 compared to T1. The current study indicates that both anesthetics did not induce oxidative stress in patients undergoing elective surgery and that propofol might exert antioxidant protection. Supported by FAPESP, Brazil #2006/59625‐6; 2010/05611‐0