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Polyamine Effects on β‐Lactam Antibiotics in Pseudomonas aeruginosa
Author(s) -
Lewis Martha,
Kwon Don
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.541.1
Subject(s) - pseudomonas aeruginosa , carbenicillin , aztreonam , spermidine , ticarcillin , microbiology and biotechnology , antibiotics , chemistry , aminoglycoside , spermine , polyamine , lactam , ceftazidime , biology , bacteria , gentamicin , biochemistry , stereochemistry , genetics , enzyme
Pseudomonas aeruginosa is a human pathogen causing a variety of diseases. Treatment of P. aeruginosa infections use β‐lactam and aminoglycoside antibiotics; however, the treatment is difficult due to multidrug resistant P. aeruginosa. Polyamines (spermidine and spermine) are cationic compounds and known as enhancing antibiotic susceptibility. In this study, polyamine effects on growth of P. aeruginosa and β‐lactam susceptibility were examined. Results showed that polyamines were non‐toxic on growth of P. aeruginosa and significantly enhanced β‐lactam susceptibility, suggesting polyamines may be used to treat multidrug resistant P. aeruginosa infections in combining with existing β‐lactam antibiotics such as Aztreonam, Carbenicillin, Ceftriaxone, and Ticarcillin.