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Strictly regulated blood glucose oscillations linked to rat mortality after severe burn injury
Author(s) -
Zhang Xing,
Cai Xiaoqing,
Li Jia,
Yan Wenli,
Gao Feng
Publication year - 2012
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.26.1_supplement.478.5
Subject(s) - burn injury , total body surface area , medicine , insulin , endocrinology , glucagon , surgery
Aim To investigate the relation of acute hyperglycemia to rat mortality after severe burn injury. Results Strictly regulated blood glucose oscillations were found in rats after severe burn injury (full‐thickness third‐degree burn injury comprising >40% of total body surface area). Within 12 h post burn injury, two peaks of blood glucose were detected at 30 min (increased 13%, p<0.05) and 3 h (increased 35%, p<0.01) respectively, coupled with increased serum insulin, glucagon and corticosteroid levels. More importantly, the second peak of blood glucose was in a highly linear relation to the first one (r2=0.78). Blood glucose of rats dying within 12 h was significantly higher in both peaks compared with those still alive after 12 h (p<0.05), while no peaks has been found in rats within 12 h after slight burn injury with extremely low mortality. In addition, early insulin treatment (2.5 IU/kg, immediately after burn injury) which suppressed the first peak and then removed the second one, largely decreased mortality via enhancing insulin sensitivity. Conclusion These strictly regulated blood glucose oscillations are highly related to rat mortality after severe burn injury. Early insulin treatment which suppresses blood glucose oscillations exerts protective effect. Supported by the State Key Program of National Natural Science Foundation of China (No. 81030005)